Article explores the use of amniotic chorionic membrane, particulate scaffolds, and autograft transplantation in musculoskeletal injury healing, comparing their mechanisms, advantages, and clinical potential.

The review highlights not only the current state of AMT but also its potential future role in advancing regenerative medicine, including emerging applications in spinal cord repair, orthopaedics, and tissue engineering. This updated synthesis aims to inform clinicians and researchers about the multifaceted applications of AMT, promoting further investigation and optimization of this promising therapeutic approach.

Amniotic‑derived products show strong potential in orthopedics, with pre‑clinical and early clinical studies demonstrating benefits in tendon, ligament, cartilage, and osteoarthritis treatments. Their regenerative matrix, growth‑factor content, and immunomodulatory properties make them a safe, accessible biologic option, though long‑term clinical data are still needed to confirm durability and outcomes.

This study evaluated a dual‑layer dehydrated human amnion–amnion membrane (dHAAM), showing strong biocompatibility, antimicrobial activity, and a rich proteomic profile with thousands of regenerative proteins. Mechanical testing confirmed reliable suture retention and variable structural properties across donor lots, highlighting both its clinical promise and the importance of standardized processing.

Article explains how human amniotic membrane (AM) is prepared, preserved, and used in medicine. It highlights AM’s unique biological properties—like being anti-inflammatory, antimicrobial, and supportive of tissue repair—and explores its applications in wound healing, ophthalmology, dentistry, and regenerative medicine. It also stresses that different processing methods (cryopreservation, dehydration, decellularization) lead to varied clinical outcomes.

This review outlines how amniotic membrane transplantation (AMT) supports healing across a wide range of ocular surface diseases through its anti‑inflammatory, anti‑scarring, and regenerative properties. It also compares preservation methods and clinical applications, emphasizing AMT’s growing role in both office‑based and surgical eye care.

This review highlights various ancient and new applications of amnion in research and clinical applications, from regenerative medicine to cancer therapy, focusing on articles published during the last decade that also revealed information regarding amnion-based products. Challenges and future perspectives of the amnion in regenerative medicine are also discussed.

This study reports promising interim results from randomized clinical trials evaluating dehydrated human amnion/chorion membrane (DHACM) for treating non-healing diabetic foot ulcers, showing accelerated wound closure and improved healing outcomes compared to standard care.

Multicentre retrospective study which analyzes wound size during clinic visits for patients being treated for either diabetic or VLUs. During each visit, the treatment consisted of debridement followed by application of DHAM. Study compares the efficacy of standalone DHAM application to hard-to-heal diabetic and venous leg ulcers with findings indicating that DHAM is an effective intervention for resolving these types of wounds.

This multicenter randomized controlled trial in Plastic and Reconstructive Surgery found that adding dehydrated human amnion/chorion allograft (dHACA) to standard care significantly improved venous leg ulcer healing, with 75% of ulcers healed at 12 weeks compared to 30% with standard care alone. The treatment was well‑tolerated, with no graft‑related adverse events, supporting dHACA as a safe and effective option for chronic venous leg ulcers.

A prospective clinical study of 21 patients undergoing lower‑extremity reconstructive foot and ankle surgery found that placing dehydrated human amnion/chorion allograft (dHACA) over deep surgical layers significantly improved postoperative healing outcomes. Patients experienced substantial gains in AOFAS scores (35.8 → 87.5) and marked reductions in pain, with no graft‑related complications, supporting dHACA as a safe adjunct that enhances recovery after complex foot and ankle procedures.

Updated meta-analysis to better understand the effectiveness and safety of human amnion/chorion membrane therapy for diabetic foot ulcers. The PubMed, Embase, Cochrane Library, and ClinicalTrial.gov databases were searched for any randomized clinical trials comparing human amnion/chorion membrane therapy and standard therapy in the treatment of diabetic foot ulcers. This meta-analysis suggests that human amnion/chorion membrane therapy as an adjuvant treatment could promote the healing of diabetic foot ulcers and has a safety profile. 

This case series of 30 children with partial‑ and full‑thickness burns found that treatment with dehydrated human amnion/chorion membrane (dHACM) achieved healing rates comparable to split‑thickness skin grafts, but with lower rates of hypertrophic scarring and contracture. Despite higher upfront product cost, the authors report reduced downstream morbidity (donor‑site pain, revisional surgeries, and transfers to higher‑level centers), suggesting dHACM is a safe, feasible, and potentially superior alternative for small‑to‑moderate pediatric burns.

In this retrospective review of complex foot and ankle wounds, adjunctive use of dehydrated amnion/chorion membrane (dHACM) was associated with higher wound‑closure rates and shorter time to healing compared with standard care alone. The findings suggest that dHACM may provide clinically meaningful benefits in managing challenging lower‑extremity wounds by supporting tissue repair and advancing progression toward closure.

PubMed and MEDLINE databases were queried and sorted based on clinical trials of patients (human subjects) treated with amniotic membrane products, with publication dates ranging from 2013 to 2017. A literature review regarding the safety and efficacy of amniotic membrane adjuncts demonstrated that patients treated with amniotic membrane products have increased rates of wound healing compared with the standard of care.

This study explores how amniotic fluid–derived stem cells interact with acellular nerve grafts, highlighting regenerative potential in peripheral nerve repair.

This research article reviews how placental tissues (especially the amniotic membrane and chorion) are being developed as biomaterials in regenerative medicine. It explains their unique biological properties—anti-inflammatory, antimicrobial, anti-scarring, and regenerative—and highlights their applications in wound healing, ophthalmology, orthopedics, neurology, and dentistry. The paper also discusses preservation methods, challenges in clinical use, and the future potential of placental-derived scaffolds.